“It is a pleasure for me to strongly recommend you, Mario. First of all, Mario has an impressive CV with experience at the FDA. He worked for me on the development of PK/PD model. We only have few data from the literature but Mario could develop with a short and agreed timeframe a model for PK prediction. Based on the model, I could validate a clinical protocol. On short notice, I invited Mario to a clinical study committee. He did a really great presentation. People (not familiar with PK/PD modeling) were enthusiastic to see the model that Mario developed. Last but not least, the committee had questions and Mario answered with live simulation… “What if we would give it twice a day? What if we would give it once a day?”. The model delivered immediately the answers. The committee was really impressed and could take important decisions on the study design.
I have no conflict of interest with Mario or Mario’s company.”

“What an exciting experience it was to work with Mario on the entrectinib PopPK Filing! Mario is an experienced PopPK modeler and an excellent programmer. He is always available to efficiently and quickly address the requests coming both from the project team and from Health Authorities.”

“Mario came to us at a critical juncture during the development of our lead clinical candidate therapy. We had to conduct a detailed PK analysis under an extremely tight deadline. He was able to review our PK data, analyze, conduct and explore various relationships with the dose, identify the critical parameters as well as covariates. He also built a model, at our request, that strategically informed our approach to dosing. Mario is very responsive and rises to the challenge even when he is working with seemingly impossible deadlines. His work is meticulous and he typically delivers ahead of schedule. He has a crisp grasp of pharmaceutical regulation especially as it pertains to pharmacometrics principles. His reports are very thorough and clear. I highly recommend Mario as a PK Consultant.”

“‘It has been my pleasure collaborating with Mario on a large exposure-response PopPK modeling effort. Mario is a hard worker, always available and dedicated, he was able to quickly adapt to our working environment and bring valuable insights into the project.”